Pfizer followed by AstraZeneca vaccine or Oxford-AstraZeneca followed by Pfizer/BioNTech vaccine, both ways covid vaccine generates high concentrations of antibodies against Coronavirus.
A new research paper from researchers running the University of Oxford-led Com-COV study published today has revealed that mixing the AstraZeneca and Pfizer coronavirus doses induces an effective immune response against COVID-19.
The study published on the Lancet pre-print server, scientists reported that both “mixed” schedules (Pfizer-BioNTech followed by Oxford-AstraZeneca, and Oxford-AstraZeneca followed by Pfizer-BioNTech) generated high concentrations of antibodies against the SARS-CoV2 spike IgG protein when doses were administered four weeks apart.
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The results of the study suggest there could be more flexibility and overlap in vaccination schedules involving the Oxford-AstraZeneca and Pfizer-BioNTech vaccines moving forward.
Professor Matthew Snape, Associate Professor in Paediatrics and Vaccinology at the University of Oxford, and Chief Investigator on the trial, said:
Vaccinating with AstraZeneca vaccine first and the Pfizer-BioNTech second induced higher antibodies and T-cell responses than Pfizer-BioNTech/Oxford-AstraZeneca, and both of these induced higher antibodies than the licensed, and highly effective “standard” two-dose Oxford-AstraZeneca schedule.
The highest antibody response was seen after the two-dose Pfizer-BioNTech schedule, and the highest T cell response was observed from Oxford-AstraZeneca followed by Pfizer jab.
The T cell response is an integral and essential part of the host immune response to to virus infection.
Professor Matthew Snape said:
Deputy Chief Medical Officer Professor Jonathan Van-Tam said:
Professor Andrew Ustianowski, NIHR Clinical Lead for the COVID-19 Vaccination Programme and Joint National Infection Specialty Lead, added:
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In May, researchers reported preliminary Com-COV data revealing more frequent mild to moderate reactions in mixed schedules compared to standard schedules, however, these were short-lived in duration.
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