Mixing coronavirus vaccines results in mild to moderate side effects for adults but comes with “no safety concerns”, a new study shows.
The research studied using alternating doses of the Oxford/AstraZeneca and Pfizer COVID-19 jabs, with either being given as the first dose, and then the other as the second.
And it found that mixing vaccines, prompted the frequency of mild to moderate symptoms and led to more people taking time off work the day after inoculation.
However, side-effects were short-lived and there were no other safety concerns.
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Researchers report that, when given at a four-week interval, both of the mixed schedules, Pfizer/BioNTech followed by Oxford/AstraZeneca, and Oxford/AstraZeneca followed by Pfizer/BioNTech, induced more frequent reactions following the second dose than the standard schedule of giving two of the same vaccine.
Reactions included symptoms like chills, fatigue, headaches and feeling feverish, and were short-lived, according to a peer-reviewed letter that has been printed in The Lancet.
And, the research suggests that as the study data was recorded in participants aged 50 and above, there is a possibility such reactions may be more prevalent in younger age groups.
The study reported reactogenicity findings only – how people feel after the vaccine – and not yet the immunogenicity findings, that is how well the mixed dosing worked at inducing an immune response.
Matthew Snape, associate professor in paediatrics and vaccinology at the University of Oxford, and chief investigator on the trial, said:
Prof Snape further said the number of symptoms did not vary too much depending on which vaccine was given first.
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He added:
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