6.5 C
New York
Sunday, September 25, 2022

A nanoparticle that can destroy tumor cells effectively

Must Read

New Study Explains Why Women Self-selecting Out Of STEM – It’s Not About Being “White Or Male” Anymore

Even though women and people of color have made small gains in STEM (Science, Technology, Engineering and Mathematics)...

Live Liver Donor Transplants Can Save More Lives In The US

A new study in the Journal of Hepatology says that liver transplants from living donors can cut...

Soldiers Who Refuse To Go To War May Face A Jail Term Up To 10 Years – Russia’s New Criminal Code

According to the official legal information portal, President Vladimir Putin has approved changes to the law to...
Avatar photo
Kamal Saini
Kamal S. has been Journalist and Writer for Business, Hardware and Gadgets at Revyuh.com since 2018. He deals with B2b, Funding, Blockchain, Law, IT security, privacy, surveillance, digital self-defense and network policy. As part of his studies of political science, sociology and law, he researched the impact of technology on human coexistence. Email: kamal (at) revyuh (dot) com

The findings, published in the Journal of the American Chemical Society, suggest a powerful new twist into photothermal therapy, an experimental cancer treatment that utilizes light-generated heat to attempt to destroy tumour cells.

A nanoparticle combination of viral coat proteins and dye molecules enables lasers to destroy tumour cells and then invites the immune system to clean up the following mess.

Scientists explain why mutations in the virus cause COVID-19 to spread so rapidly

Photothermal therapy mainly involves injecting inorganic nanoparticles, such as gold nanorods, into a tumour and then heating the particles with lasers to selectively eliminate tumour cells. The cell debris then stimulates the immune system, which attacks what remains of the tumor. However, most studies have found that this one-two punch is insufficient and frequently leaves cancer cells that potentially spread behind. Additionally, when gold accumulates in the body, it can be poisonous.

Arezoo Shahrivarkevishahi, a graduate student in chemist Jeremiah Gassensmith’s lab at the University of Texas in Dallas, and her colleagues instead used viruslike particles (VLPs)—structures derived from virus proteins but lacking viral genetic material.

This new drug combination effectively fights against COVID infection

They created VLPs by reusing proteins from bacteriophage Q that self-assemble into the virus’s coat. They next painted each particle’s surface with an average of 212 molecules of croconium dye, which is harmless and absorbs near-infrared light, by altering functional groups on the proteins. That much dye, Shahrivarkevishahi explains, “may generate a lot of heat.”

Not only is the generated particle biocompatible, but because it mimics viruses and is recognised by the immune system, she believes it may elicit a stronger immunogenic response than phototherapy with inorganic particles. Additionally, the researchers discovered that tumor cells absorb the nanoparticle twice as efficiently as they absorb dye alone.

A new way to detect the risk of psychotic illnesses in children early

The researcher applied the particles into breast tumour cells implanted into mice’s mammary glands and then activated the therapy with near-infrared laser light applied to the skin over the tumor. Mice given this combined treatment—VLPs adorned with dye—had a 70 percent reduction in initial tumors, a 85 percent reduction in metastases, and a 30 percent increase in survival when compared to mice given saline injections. Additionally, the particles outperformed bare VLPs or dye alone in terms of tumor reduction.

While the current work demonstrates a simplified form of the strategy, covalently linking Q coat proteins or another VLP to chemotherapy or other cancer medications may further enhance the treatment’s efficacy.

An antiviral pill that cuts the risk of hospitalization or death from Covid by half – trials show

Image Credit: Getty

Source: https://doi.org/10.1021/jacs.1c05090

You were reading: A nanoparticle that can destroy tumor cells effectively

- Advertisement -
- Advertisement -

Latest News

- Advertisement -

More Articles Like This

- Advertisement -