A new drug, that destroys a protein that fuels acute myeloid leukaemia (AML) – a rare and particularly aggressive form, could cure one of the deadliest blood cancers has been developed by British scientists.
Scientists are hopeful that the technique could lead to treatments for other forms of cancer as well.
In experiments on humans and mice, the compound stopped the disease in its tracks. Clinical trials are expected within a year.
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It blocked the cancerous effect caused by over-expression of the enzyme, known as METTL3.
The medication inhibited its action in lab rodents with AML – and tissue cultured from actual patients.
Study leader Professor Tony Kouzarides, of Cambridge University, said:
The former is the ‘blueprint’ and the latter the ‘worker’ – responsible for converting genetic information into the necessary products for life.
Prof Kouzarides said:
As described in the journal Nature – it could help treat a range of cancers.
Our genetic code is written in DNA. To generate proteins – molecules vital to the function of organisms – it first needs to be changed into RNA.
Enzymes then make the chemical alterations. But occasionally they become mis-regulated – leading to an over-abundance.
Four years ago Prof Kouzarides and colleagues traced AML to the over-production of METTL3.
It occurs when bone marrow makes abnormal white blood cells known as myeloid cells – which normally protect against infection and the spread of tissue damage.
It spreads rapidly – usually requiring immediate treatment.
In tests on cell lines from individuals with AML the molecule, called STM2457, significantly reduced their growth and proliferation.
It also triggered a process known as apoptosis or ‘cell death’ – killing off the cancerous cells.
The AML cells from patients were then transplanted into immuno-compromised mice to model the disease.
When the animals were injected with STM2457 it impaired the spread of the disease and dramatically prolonged lifespan.
It also reduced the number of leukaemic cells in the mouse bone marrow and spleen while showing no toxic side effects – including no weight loss.
Co-author Dr Konstantinos Tzelepis, also from Cambridge, said:
On Sunday, former Coventry City footballer Ashley Cain announced his eight-month-old daughter Azaylia had died from AML.
Cain, now a reality TV star, and partner Safiyya Vorajee had raised more than $2.0m or about £1.5m earlier this year to fund specialist treatment for Azaylia in Singapore.
But the 30-year-old told his Instagram followers last month she had become too ill for the treatment.
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Michelle Mitchell, chief executive of Cancer Research UK, said:
Prof Kouzarides and colleagues have set up spin-out company STORM Therapeutics. It specialises in translating research into the discovery of first-in-class drugs in oncology and other diseases.