What happens in the body of people vaccinated against coronavirus with different vaccines, is such vaccination effective?
German Chancellor Angela Merkel and Italian Prime Minister Mario Draghi were vaccinated against the coronavirus with two different vaccines.
Merkel received her first dose in April with AstraZeneca and the second with Moderna a few days ago. Draghi, after being injected with the Astrazeneca vaccine, made a second Pfizer drug.
How effective is this vaccination?
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The US Centers for Disease Control and Prevention (CDC) indicated that US-approved vaccines are not interchangeable with each other or with other COVID-19 vaccines. At the same time, in exceptional situations for the second dose, any available mRNA vaccine against coronavirus can be used. In this case, at least 28 days should elapse after the first injection.
Vaccination with another drug can be completed, for example, if the second dose of the vaccine that the patient first received is not available, or if the manufacturer of the first vaccine is unknown.
At the same time, the Center indicated that the safety and efficacy of the blended product line was not evaluated.
Scientists from the University of Saar in Germany found that people who received the first vaccine with AstraZeneca and the second with BioNTech / Pfizer had a much higher immune response than patients who received the same vaccine twice.
The German university’s press statement on the findings of the study emphasizes that the results are preliminary and have not yet been fully scientifically evaluated. Before the publication of the official findings, the research team intends to study the role of factors such as age and gender of patients, as well as to find out which combinations of vaccines can cause more serious side effects.
The trial, which was conducted over several months at a university hospital in Homburg, Saarland, involved 250 people, divided into three groups. The first received two AstraZeneca shots, the second was vaccinated twice with BioNTech / Pfizer, and the remaining participants were vaccinated with a combination of the two vaccines.
The researchers found that people vaccinated with a double dose of BioNTech / Pfizer and a combination of the two vaccines produced about ten times more antibodies than those who received a double dose of AstraZeneca.
Vaccination with two different vaccines was even more effective than a double dose of BioNTech / Pfizer.
Similar conclusions were made in the course of the CombivacS study conducted at the Carlos III Institute of Health in Madrid. Two-thirds of the participants in the Madrid study were vaccinated with BioNTech / Pfizer after the first AstraZeneca vaccination.
Magdalena Campins, who conducted the study at the Val d’Hebron University Hospital in Barcelona, said that those who were vaccinated with two different vaccines, after the second vaccination, began to produce much higher levels of antibodies, and these antibodies were able to recognize and inactivate SARS-CoV-2 in laboratory tests.
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However, one of the problems with the Spanish study – besides the fact that its results are not yet definitive and peer-reviewed – is that it does not include a control group of people who received two doses of the same vaccine, so a direct comparison between the two groups is not possible.
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