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How safe you are after first dose of COVID-19 mRNA vaccine?

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Aakash Molpariya
Aakash started in Nov 2018 as a writer at Revyuh.com. Since joining, as writer, he is mainly responsible for Software, Science, programming, system administration and the Technology ecosystem, but due to his versatility he is used for everything possible. He writes about topics ranging from AI to hardware to games, stands in front of and behind the camera, creates creative product images and much more. He is a trained IT systems engineer and has studied computer science. By the way, he is enthusiastic about his own small projects in game development, hardware-handicraft, digital art, gaming and music. Email: aakash (at) revyuh (dot) com

A recent research released on the preprint site medRxiv* evaluated the effectiveness of mRNA vaccines against SARS CoV-2 and Covid 19 variants of concern (VOC) among HCWs after their first and second doses. Additionally, this research evaluated the efficacy of a single dosage of the mRNA vaccine 16 weeks after immunisation.

Due to a vaccine shortage, the Quebec Immunization Committee (QIC) advised that the Canadian province of Quebec postpone administering the second dose of the COVID-19 vaccine in order to maximise coverage of the first dose.

This suggestion was made to save the majority of the high-risk population, which includes older adults and frontline workers, from severe COVID-19 infection and mortality.

The researchers accomplished this by comparing vaccination rates among HCWs who tested positive for SARS-CoV-2 to those who tested negative. The present research comprised 5,316 cases and 53,160 controls.

A single dose of the mRNA vaccine was found to have a VE of 70% against any SARS-CoV-2 infection and 73% against COVID-19 disease in the trial group.

However, VE was estimated to be 86 percent against any SARS-CoV-2 infection and 93 percent against COVID-19 disease in HWCs who got two doses of the vaccine. VE against SARS-CoV-2 hospitalization rates for the recipients of both one and two doses was comparably high at >95%.

The researchers found that a single dose of an mRNA vaccine conferred significant protection against SARS-CoV-2 infection that lasted at least 16 weeks after immunisation.

This is probably the paper’s most significant addition, since prior research has failed to show vaccination efficacy beyond 8 weeks.

These results support the conclusion that the gap between the first and second doses of the vaccine may be extended by up to four months in the case of a vaccine supply shortage.

When the present research was performed, the main circulating strain of SARS-CoV-2 in Quebec was the Alpha (B.1.1.7) variety.

As a result, the authors claim that a single dosage of the vaccine was effective against the Alpha strain in 60% of HCWs.

This result is similar with previous research performed in another Canadian province, British Columbia, which demonstrated a 67 percent VE efficacy against COVID-19 Alpha infection in individuals over the age of 70 after a single dosage.

Photo by Spencer Platt/Getty Images

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