According to major research that has tested almost all of a small Italian town,:
- 20% people can infect up to 79% of population
- Antibodies remain high for nine months
- Re-infection can boost the immune system
The research paper, published in the journal Nature Communications, focused on the town of Vo which became the centre of the country’s coronavirus pandemic in February 2020 when it recorded Italy’s first death.
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Researchers from the University of Padua and Imperial College London have already tested antibodies against COVID-19 in over 85% of the town’s 3,000 inhabitants.
The results of the study showed that 98.8 percent of individuals who were infected during the pandemic’s initial wave still had detectable antibody levels nine months later, regardless of whether their illness was symptomatic or not.
Residents’ antibody levels were determined using three distinct “assays,” or procedures that identified distinct types of antibodies directed against distinct components of the virus.
The findings indicated that all antibody levels decreased when the body recovered from infection, although the rate of drop varied according to the assay used.
Additionally, the researchers discovered many instances of individuals’ antibody levels increasing, indicating that possible viral re-infections boosted the immune system.
Dr Ilaria Dorigatti of Imperial College London stated:
Additionally, the researchers examined how the illness transmitted to household members and discovered that there was a 25% probability of the virus being transferred in this manner.
Surprisingly, the study also discovered that the vast majority of transmissions, 79%, were generated by 20% infected with the virus.
Another aspect of the study was an analysis of two mass PCR testing campaigns conducted in February and March, as well as the antibody surveys in May and November, which allowed them to analyse the impact of various control measures.
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This data showed that, in the absence of case isolation and short lockdowns, manual contact tracing alone would not have been enough to suppress the epidemic.
Project lead Professor Andrea Crisanti, from the University of Padua, said:
Dr Dorigatti added:
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Photo by Francine Orr / Los Angeles Times via Getty Images