HomeScience and ResearchScientific ResearchResearchers Map 140,000 DNA Regions In The Largest Genetic Atlas Ever

Researchers Map 140,000 DNA Regions In The Largest Genetic Atlas Ever

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We are now one step closer to having a completely realized map to overlay with the human genome thanks to the new catalogue. This kind of work will enable scientists all over the world to investigate novel cures, medications, and a deeper comprehension of human and animal diseases quickly.

Newly published research suggests that medical and life science researchers will benefit from the most complete atlas of zebrafish genetic data to date.

Researchers will be able to examine numerous cancers (such as skin cancer), heart disease, and neurodegenerative illnesses more effectively thanks to the atlas. It could be beneficial for more researchers to substitute mammal models in their research.

The DANIO-CODE project, a group of 27 institutes from around the nation, collaborated to categorize available open-access datasets compensated with newly generated data. This research led to the identification of 140,000 DNA regions that regulate gene expression in zebrafish.

The study of zebrafish, the second-most-used animal model for medical and life sciences research, is based on 1,802 samples containing millions of data points each and provides the most comprehensive picture of candidate DNA regions for transgenic breeding and genetic research into the development and progression of diseases.

The article, which was published today in Nature Genetics, describes DNA components involved in several embryonic developmental stages and advances our knowledge of the genetic similarity between zebrafish and mice.

“The cataloguing of genetic information for zebrafish,” according to Ferenc Mueller, director of the study’s collaboration and professor of developmental genetics at the University of Birmingham, “is a significant breakthrough that could underpin some of the most exciting medical and life sciences developments for years to come.

Over 50 experts from around the world have been brought together by professors Carsten Daub of the Karolinska Institutet and Boris Lenhard of Imperial College London. The resulting atlas/map demonstrates how a bottom-up initiative for cross-border collaboration can have a positive impact on our scientific community. Researchers will be able to use the genetic information in the catalogue made by the DANIO-CODE consortium in their future studies.

Zebrafish are a very helpful model for scientists. They develop openly as embryos and have extraordinary regeneration abilities, making them excellent research subjects for a number of diseases and ailments. Researchers have already learned a lot about the human condition from these properties.

“Now, with our new catalogue, we move one step closer to having a fully realised map from which to overlay with the human genome. This kind of activity will allow researchers around the world to pursue at pace novel treatments, drugs, and a better understanding of the human and animal disease.”

According to Karolinska Institutet’s Carsten Daub, who led the data integration, “this extensive study consolidates all individual datasets into one framework allowing researchers across the world to address questions which could not be addressed by the individual studies.”

Image Credit: Getty

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