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Post-Coronavirus: the annoying symptom that remains in half of patients

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Kamal Saini
Kamal S. has been Journalist and Writer for Business, Hardware and Gadgets at Revyuh.com since 2018. He deals with B2b, Funding, Blockchain, Law, IT security, privacy, surveillance, digital self-defense and network policy. As part of his studies of political science, sociology and law, he researched the impact of technology on human coexistence. Email: kamal (at) revyuh (dot) com

High prevalence of chronic fatigue after coronavirus infection and regardless of the severity of COVID-19 disease show new evidence brought to light by a recent scientific study

The research papers presented at the ESCMID (European Society of Clinical Microbiology and Infectious Diseases) conference on Covid-19 disease shows that chronic fatigue occurs in more than half of patients recovering from COVID-19, regardless of the severity of their infection.

“Fatigue is a common symptom in those with symptomatic COVID-19 infection. Although current data on SARS-CoV-2 infection have been adequately characterized, the medium and long-term effects of the infection remain unexplored,” Liam Townsend from Trinity College Dublin who conducted the research.

“In particular, concerns are being raised about the fact that SARS-CoV-2 has the potential to cause chronic fatigue, even after patients recover. In our study, we investigated whether patients who recovered from a coronavirus infection experienced fatigue after physical recovery and whether there was a relationship between severe fatigue and various other clinical parameters. We also looked at the values ​​of disease indicators after the end of the infection,” he added.

The authors used a widely used scale (CFQ-11) to determine fatigue in patients who recovered and assessed the severity of patients’ initial infection (need to be admitted to hospital and ICU) as well as pre-existing conditions, including depression. They also examined various immune defense markers (white blood cells, C-reactive protein, interleukin-6 and sCD25).

The study included 128 participants (average age 50 years, 54% women) enrolled approximately 10 weeks after clinical recovery from infection, half of whom reported persistent fatigue (52.3%, 67/128) at that time.

As the data showed, there was no correlation between the severity of COVID-19 (need for hospitalization, respiratory support or ICU) and subsequent fatigue, nor between the classic laboratory markers of inflammation, cell rotation (number or white blood cell ratio, lactic dehydrogenase, C-reactive protein) or pro-inflammatory molecules (IL-6 or sCD25) and post-disease fatigue.

The fact is that the women and people with a pre-existing diagnosis of depression/anxiety were overrepresented to those with fatigue. Also, although women accounted for more than half of the patients in the study (54%), two-thirds of those with chronic fatigue (67%) were women. And while only one of the 61 people (1.6%) without fatigue had a history of anxiety or depression, the ratio reached 13.4% (9/67) in those with chronic fatigue.

The authors conclude: “Our findings show a significant burden of post-fatigue in individuals with previous SARS-CoV-2 infection, after the intense phase of COVID-19 disease. The study emphasizes the importance of evaluating those recovering from COVID-19 with symptoms of severe fatigue, regardless of the severity of the initial disease, and may be able to identify a significant group of patients for further studies and early intervention. It also supports the use of non-drug interventions to manage fatigue, which should be individualized to the needs of patients and may include lifestyle modifications, cognitive behavioral therapy and exercise where and when possible.”

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