The World Health Organization’s chief scientist on Monday warned against mixing and combining COVID-19 vaccinations from various manufacturers on, calling it a “dangerous trend” because of the lack of evidence on the health consequences.

“It’s a little bit of a dangerous trend here. We are in a data-free, evidence-free zone as far as mix and match,” in an online briefing, Soumya Swaminathan said.

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“It will be a chaotic situation in countries if citizens start deciding when and who will be taking a second, a third and a fourth dose.”

Last month, one study from researchers running the University of Oxford-led Com-COV study, revealed that mixing the AstraZeneca and Pfizer coronavirus doses induces an effective immune response against COVID-19.

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In the study published on the Lancet pre-print server, scientists reported that both “mixed” schedules (Pfizer-BioNTech followed by Oxford-AstraZeneca, and Oxford-AstraZeneca followed by Pfizer-BioNTech) generated high concentrations of antibodies against the SARS-CoV2 spike IgG protein when doses were administered four weeks apart.

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In May, researchers reported preliminary Com-COV data revealing more frequent mild to moderate reactions in mixed schedules compared to standard schedules, however, these were short-lived in duration.

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