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Why second dose of Pfizer covid vaccine is more violent than AstraZeneca: Expert clarifies

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Kuldeep Singh
Kuldeep is a Journalist and Writer at Revyuh.com. He writes about topics such as Apps, how to, tips and tricks, social network and covers the latest story from the ground. He stands in front of and behind the camera, creates creative product images and much more. Always ready to review new products. Email: kuldeep (at) revyuh (dot) com

Many people struggle with side effects after the second dose of Pfizer Coronavirus Vaccine; with AstraZeneca, on the other hand, the first dose is much more violent than the next. But why is it like that? 

Like Moderna, Pfizer is an mRNA vaccine, mRNA stands for messenger ribonucleic acid. A genetic blueprint is transported via the nucleic acid, whereby the cells produce the corona protein themselves. 

The result: the body reacts to it and builds up its defenses.

But why is the reaction to the second vaccination more violent with the mRNA vaccine than with the first vaccination? 

According to experts consulted by Revyuh, the mRNA is first introduced into the cell and it takes a while until enough proteins are produced, the immune response is slower with an mRNA vaccine. The second jab is then a bit more violent because the immune system is already a bit trained and has had contact with the foreign protein and can therefore produce antibodies in a faster immune response.

With AstraZeneca Covid Vaccine it’s the other way around – why?

Astrazeneca vaccine is a vector vaccine. It uses a virus as a means of transport, a so-called vector. 

Since you basically vaccinate a virus with a vector vaccine and the immune system reacts to the vector, the first immune reaction is simply stronger.

Why vaccine side effects occur?

Most people react relatively harmlessly to the vaccination. For example, some react more strongly to the tick vaccination than to the corona vaccination.

An immune reaction in the body involves a number of biochemical processes that release messenger substances that lead to fever. 

But such reactions would not only occur with a corona vaccination.

Should you worry if you don’t see any side effects?

Some worry that if they haven’t had a severe vaccination reaction, they may not be immunized at all. 

Whether someone reacts weaker or stronger has nothing to do with vaccination protection.

If you want to check exactly how good the immune reaction to the vaccination was, you can have an antibody titer taken. The titer is a measure of the number of certain antibodies in the blood. 

This enables the antibody level to be determined two weeks after the vaccination, how high it is and how well the immune system has responded to it.

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